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Cell Cultivation Top Page ＞3D Cell Culture ＞Spheroid Formation Principle
It is believed that the cells grow three-dimensionally by elongating pseudopods using as their foothold the fine-structure scaffold.
When using the conventional flat cultivation plate (without the fine-structure), the cells form as a monolayer, as they do not have the foothold.
Also, it has been noted that depending on the cell species and the cell size the cells have favorite "pattern size" and "form".
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As this constitutes a wide research field which can constitute one grand academic theme, this principle awaits its verification in future research. |
What is a pseudopod?
The temporary projection of eukaryotic cells formed when cells migrate.
They are involved in the cancer infiltration and metastasis in the body.
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